Famine in Niger, war and famine in Sudan, famine and disease after the tsunami, predatory landlords, dirty drinking water, the abuse of women and children, yet more war everywhere, AIDS, hurricanes, the impossible life of the subsistence farmer, drought, endless cycles of poverty and corruption, malaria, and still more war.
What's a person to do?
Give a few bucks to Oxfam if nothing else. 77% of their donations and 90% of their emergency fund donations go directly to operations. They help in emergencies and crises, and they fight the root causes of the world's miseries too. They do it locally, with global reach.
For those outside the U.S., the donation link is this one.