In my case I just realized in the last few days that I'll probably never have a real, satisfying romantic relationship. Looking back at my attempts at dating, there are a few abortive attempts of varying but temporary success and a couple of truly painful relationships of fairly short term. Success rate is zero.
I often meet people I'm interested in; they are never interested in me. The actual success rate in the last ten years has been zero. Periodically I forget this and try to get somewhere with someone, but the result is consistently negative, often with a nasty blowback that leaves a friendship scarred and smoldering.
Given all this, I think it's best that I just seal up that part of life and concentrate on what I'm good at. Lately that seems to be computer system administration, cooking, and being a thoroughly neutered platonic friend to whom women may complain about their boyfriends and husbands.
Two cheers for the urge to reproduce!